Invention Grant
- Patent Title: Lipids and complexes for the delivery of biologically-active material to cells
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Application No.: US16082785Application Date: 2017-03-10
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Publication No.: US11098006B2Publication Date: 2021-08-24
- Inventor: Helen Claire Hailes , Alethea Bernice Tabor , Mohn Firouz Mohd Mustapa , Stephen Lewis Hart , Aristides Tagalakis
- Applicant: RYBOQUIN COMPANY LTD
- Applicant Address: GB London
- Assignee: RYBOQUIN COMPANY LTD
- Current Assignee: RYBOQUIN COMPANY LTD
- Current Assignee Address: GB London
- Agency: Nexsen Pruet, LLC
- Agent David S. Bradin
- Priority: GB1604235 20160311
- International Application: PCT/GB2017/050664 WO 20170310
- International Announcement: WO2017/153779 WO 20170914
- Main IPC: C07C217/28
- IPC: C07C217/28 ; A61K47/54 ; A61P35/00
Abstract:
A lipid comprising a tri-chain cation having a cationic head group and three or more C7-24 hydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated with a co-lipid) into a LPD complex.
Public/Granted literature
- US20190084923A1 LIPIDS AND COMPLEXES FOR THE DELIVERY OF BIOLOGICALLY-ACTIVE MATERIAL TO CELLS Public/Granted day:2019-03-21
Information query
