Invention Grant
- Patent Title: Englerin derivatives for treatment of cancer
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Application No.: US16628768Application Date: 2018-07-05
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Publication No.: US11098054B2Publication Date: 2021-08-24
- Inventor: John A. Beutler , Antonio Echavarren , William Chain , David Beech , Zhenhua Wu , Jean-Simon Suppo , Fernando Bravo , Hussein Rubaiy
- Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services , Fundacio Institut Catala D'Investigacio Quimica , University of Delaware , University of Leeds , Universitat Rovira I Virgili
- Applicant Address: US MD Bethesda; ES Tarragona; US DE Newark; GB Leeds; ES Tarragona
- Assignee: The United States of America,as represented by the Secretary,Department of Health and Human Services,Fundacio Institut Catala D'Investigacio Quimica,University of Delaware,University of Leeds,Universitat Rovira I Virgili
- Current Assignee: The United States of America,as represented by the Secretary,Department of Health and Human Services,Fundacio Institut Catala D'Investigacio Quimica,University of Delaware,University of Leeds,Universitat Rovira I Virgili
- Current Assignee Address: US MD Bethesda; ES Tarragona; US DE Newark; GB Leeds; ES Tarragona
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2018/040910 WO 20180705
- International Announcement: WO2019/010298 WO 20190110
- Main IPC: C07D493/08
- IPC: C07D493/08 ; A61P35/00 ; C07D495/08 ; C07D471/08
Abstract:
Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.
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