Invention Grant
- Patent Title: Triphenylphosphonium-tethered tetracyclines for use in treating cancer
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Application No.: US16606392Application Date: 2018-04-20
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Publication No.: US11098073B2Publication Date: 2021-08-24
- Inventor: Tim Sparey , Andrew Ratcliffe , David Hallett , Edward Cochrane , Gilbert Lassalle , Alexandre Froidbise , Brett Stevenson
- Applicant: Oxford University Innovation Limited
- Applicant Address: GB Oxford
- Assignee: Oxford University Innovation Limited
- Current Assignee: Oxford University Innovation Limited
- Current Assignee Address: GB Oxford
- Agency: Foley Hoag LLP
- Agent Dana M. Gordon
- Priority: GB1706319 20170420,GB1721748 20171222
- International Application: PCT/EP2018/060231 WO 20180420
- International Announcement: WO2018/193114 WO 20181025
- Main IPC: C07F9/535
- IPC: C07F9/535 ; A61P35/00
Abstract:
This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.
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