Invention Grant
- Patent Title: Method for high level production of CRM197
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Application No.: US16606958Application Date: 2018-04-19
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Publication No.: US11098089B2Publication Date: 2021-08-24
- Inventor: Balamurali Masilamani , Rajan Sriraman , Mandar Shirish Dixit , Deviprasanna Chakka , Satyam Naidu Sureddi , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla
- Applicant: Biological E Limited
- Applicant Address: IN Telangana
- Assignee: Biological E Limited
- Current Assignee: Biological E Limited
- Current Assignee Address: IN Telangana
- Agency: Perkins Coie LLP
- Priority: IN201741014335 20170422
- International Application: PCT/IN2018/050235 WO 20180419
- International Announcement: WO2018/193475 WO 20181025
- Main IPC: C12N1/20
- IPC: C12N1/20 ; A61K39/05 ; A61K39/385 ; C12P21/00 ; C07K14/34
Abstract:
The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.
Public/Granted literature
- US20200277341A1 AN IMPROVED METHOD FOR HIGH LEVEL PRODUCTION OF CRM197 Public/Granted day:2020-09-03
Information query
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