A wireless device includes multiple RF chains, one or more processing modules, a switching circuit and a processor. The RF chains operate in multiple RF bands, and at least one RF chain is configurable to operate at a RF band selected from the RF bands. The processing modules are configurable to process signals communicated with the RF chains. The switching circuit routes signals between RF chains and processing modules in accordance with a routing plan. In response to an event that warrants reconfiguration, the processor re-allocates resources, including (i) allocating one or more RF chains to respective RF bands, (ii) allocating one or more processing modules to process signals associated with the RF bands, and (iii) setting the routing plan to route signals between pairs of RF chains and processing modules allocated to a common RF band. The processor communicates wirelessly with remote devices in accordance with the operational reconfiguration.