An anti-bacterial lighting device includes a translucent housing, a first light source, a second light source, an air-inflow port, and an air circulation mechanism. The translucent housing is air-permeable and coated with an anti-bacterial photocatalyst on its surface. The first light source is a visible light source emitting a visible light with a spectral power distribution (SPD)>95% in a visible light wavelength range (>400 nm). The second light source is a far-UVC light source emitting a non-visible light with an SPD>90% in a 200 nm˜230 nm wavelength range. The lights of the first light source and the second light source shine through the translucent housing and activates the anti-bacterial photocatalyst on the housing. The air circulation mechanism sucks an ambient air into the housing through the air-inflow port and forces the air out through the air-permeable housing.