A knee brace with an articulation assembly connectable with a first cuff movable with respect to the articulation assembly about a first location defining a first pivot axis between the first cuff and articulation assembly, and movable about a second location defining a first rotation axis between the first cuff and articulation assembly. The knee brace may have a second cuff connectable with the articulation assembly and movable with respect to the articulation assembly about a third location defining a second pivot axis between the second cuff and articulation assembly. The second cuff is movable about a fourth location defining a second rotation axis between the second cuff and articulation assembly. The first pivot axis and first rotation axis may intersect each other or be offset from intersecting each other, the second pivot axis and second rotation axis may intersect each other or be offset from intersecting.