Invention Grant
- Patent Title: Small molecule inhibitors of bacterial efflux pumps and methods of using same
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Application No.: US16497315Application Date: 2018-03-27
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Publication No.: US11110080B2Publication Date: 2021-09-07
- Inventor: Abigail L. Reens , Amy L. Crooks , Corrella S. Detweiler
- Applicant: The Regents of the University of Colorado, a body Corporate
- Applicant Address: US CO Denver
- Assignee: The Regents of the University of Colorado, a body Corporate
- Current Assignee: The Regents of the University of Colorado, a body Corporate
- Current Assignee Address: US CO Denver
- Agency: Snell & Wilmer LLP
- International Application: PCT/US2018/024640 WO 20180327
- International Announcement: WO2018/183382 WO 20181004
- Main IPC: A61K31/426
- IPC: A61K31/426 ; A61K31/506 ; A61K31/517 ; A61K31/65 ; A61K38/12 ; C12Q1/18
Abstract:
An empirical Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae (SAFIRE) was developed. Using this methodology, a library of small molecules and identified antimicrobials that are cell permeable and non-host-toxic were screened. Inhibitors of bacterial efflux pumps were identified as being implicated in antibiotic resistance and are attractive therapeutic targets for antimicrobials.
Public/Granted literature
- US20200022961A1 SMALL MOLECULE INHIBITORS OF BACTERIAL EFFLUX PUMPS AND METHODS OF USING SAME Public/Granted day:2020-01-23
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