Invention Grant
- Patent Title: Water soluble O-glycosyl flavonoid compositions and methods for preparing same
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Application No.: US16660111Application Date: 2019-10-22
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Publication No.: US11110109B2Publication Date: 2021-09-07
- Inventor: Naoto Yamaguchi , Yui Sudaka , Mitsunori Ono
- Applicant: Alps Pharmaceutical Ind. Co., Ltd.
- Applicant Address: JP Gifu
- Assignee: Alps Pharmaceutical Ind. Co., Ltd.
- Current Assignee: Alps Pharmaceutical Ind. Co., Ltd.
- Current Assignee Address: JP Gifu
- Agency: Cesari & McKenna, LLP
- Main IPC: A61K31/7048
- IPC: A61K31/7048 ; A61K9/28 ; A61K47/10 ; A61K9/06 ; A61K9/08 ; A61K9/48
Abstract:
A water-soluble composition including an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and ascorbic acid or an alkali salt of ascorbic acid. The O-glycosyl flavonoid compound is rutin, isoquercitrin, or hesperidin, and a molar ratio between the O-glycosyl flavonoid compound and the sugar alcohol is 1:4.0-12.0. Also provided is a method for making the above-described water-soluble composition by combining the O-glycosyl flavonoid compound, L-arginine, the sugar alcohol, and ascorbic acid or an alkali salt thereof to form a mixture, and heating it at 110° C.-140° C. to melt the mixture.
Public/Granted literature
- US20210113599A1 WATER SOLUBLE O-GLYCOSYL FLAVONOID COMPOSITIONS AND METHODS FOR PREPARING SAME Public/Granted day:2021-04-22
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