Invention Grant
- Patent Title: Method of expanding NK cell and composition for culturing
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Application No.: US16281372Application Date: 2019-02-21
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Publication No.: US11110126B2Publication Date: 2021-09-07
- Inventor: Kyung-Mi Lee , Jeongwon Sohn , Seon Ah Lim , Jang-Mi Lim
- Applicant: Korea University Research and Business Foundation
- Applicant Address: KR Seoul
- Assignee: Korea University Research and Business Foundation
- Current Assignee: Korea University Research and Business Foundation
- Current Assignee Address: KR Seoul
- Agency: Fox Rothschild LLP
- Priority: KR10-2015-0098269 20150710,KR10-2016-0085642 20160706
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; A61K35/17 ; C12N5/0783 ; A61K35/00 ; A61K35/02 ; A61K35/04 ; A61K39/00
Abstract:
Provided are a method of ex-vivo culture of natural killer (NK) cells by treating the cells with a reactive oxygen species (ROS) inhibitor and/or a p53 protein inhibitor; and a composition comprising the cultured NK cells. By reducing the activity of ROS and p53 proteins during ex-vivo culture, NK cells may have achieved greater expansion efficiency without altering their anti-tumor cytotoxicity.
Public/Granted literature
- US20190183995A1 METHOD OF EXPANDING NK CELL AND COMPOSITION FOR CULTURING Public/Granted day:2019-06-20
Information query
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