The present disclosure pertains to a pressure support system configured to identify respiratory events of a subject. The system is configured to produce and analyze signals pertaining to one or more parameters of the pressurized flow of breathable gas to identify respiratory events. The respiratory events may include coughs and/or other respiratory events. The parameters may comprise a pressure, flow and/or volume of the pressurized flow of breathable gas. In some embodiments, cough detection may be based on a vibration in pressure, a negative spike in flow, a cessation in flow, and/or a large insufflation. In some embodiments, the system comprises one or more of a pressure generator, a subject interface, one or more sensors, a processor, a user interface, electronic storage, and/or other components.