A plumbing clog removal apparatus that includes a vacuum chamber having an inlet, an outlet, and a compressor port. The clog removal apparatus also includes an inlet seal disposed at the vacuum chamber inlet. The vacuum chamber inlet seal is movably coupled to the vacuum chamber inlet and is movable between an open position and a closed position. The plumbing clog removal apparatus also includes, an outlet seal disposed at the vacuum chamber outlet. The outlet seal is movably coupled to the vacuum chamber outlet and is movable between an open position and a closed position. The vacuum chamber also includes an air compressor fluidically connected to the vacuum chamber compressor port. The compressor is configured to remove air from the compressor chamber and form a low pressure condition inside the vacuum chamber.