A cushion structure and a package box are provided, which relate to the technical field of a protection pad. The cushion structure comprises a cushion pad which includes a multi-layered folding structure and a plurality of folding layers. One end of one folding layer is connected to one head of another folding layer neighboring to the one of the folding layers, and the folding layers are disposed in an overlapped manner after being folded. An accommodating space is formed between neighboring two of the folding layers, and the accommodating space is configured to accommodate an object. A through hole is disposed on the folding layer to prevent the object from sticking with the folding layer. A reserved pad protrudes from an edge of each folding layer, and two surfaces of the reserved pad are respectively coplanar with two surfaces of the each folding layer.