Invention Grant
- Patent Title: Benzothia(di)azepine compounds and their use as bile acid modulators
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Application No.: US17144568Application Date: 2021-01-08
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Publication No.: US11111224B2Publication Date: 2021-09-07
- Inventor: Per-Göran Gillberg , Ingemar Starke , Santosh S. Kulkarni
- Applicant: Albireo AB
- Applicant Address: SE Gothenburg
- Assignee: Albireo AB
- Current Assignee: Albireo AB
- Current Assignee Address: SE Gothenburg
- Agency: Fish & Richardson P.C.
- Priority: IN201911049983 20191204
- Main IPC: C07D285/36
- IPC: C07D285/36 ; A61K31/554 ; A61P3/06 ; A61P1/16 ; A61P1/12 ; A61P3/10 ; A61P1/04
Abstract:
The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
Public/Granted literature
- US20210171480A1 BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS Public/Granted day:2021-06-10
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