- Patent Title: Crystal form of 2-(6-methyl-pyridin-2-yl)-3-yl-[6-amido-quinolin-4-yl]-5,6-dihydro-4H-pyrrolo[1,2-B]pyrazole, preparation method therefor and pharmaceutical composition thereof
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Application No.: US16495037Application Date: 2017-03-17
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Publication No.: US11111248B2Publication Date: 2021-09-07
- Inventor: Xiaohong Sheng , Xiaoxia Sheng , Jing Wang
- Applicant: Hangzhou SoliPharma Co., Ltd.
- Applicant Address: CN Zhejiang
- Assignee: Hangzhou SoliPharma Co., Ltd.
- Current Assignee: Hangzhou SoliPharma Co., Ltd.
- Current Assignee Address: CN Zhejiang
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/CN2017/077081 WO 20170317
- International Announcement: WO2018/165979 WO 20180920
- Main IPC: A61K31/47
- IPC: A61K31/47 ; C07D215/48 ; C07D487/04
![Crystal form of 2-(6-methyl-pyridin-2-yl)-3-yl-[6-amido-quinolin-4-yl]-5,6-dihydro-4H-pyrrolo[1,2-B]pyrazole, preparation method therefor and pharmaceutical composition thereof](/abs-image/US/2021/09/07/US11111248B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a crystal form of 2-(6-methyl-pyridin-2-yl)-3-(6-amido-quinolin-4-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole (Galunisertib or LY2157299), represented by formula (I). Compared with the known solid form of Galunisertib, the crystal form of the present invention has advantages in terms of solubility, hygroscopicity, crystal stability, morphology and the like. The present invention also relates to a process of preparing the crystal forms of Galunisertib, a pharmaceutical composition thereof and a use thereof in the preparation of a medicament for the prevention and/or treatment of diseases associated with TGF-beta.
Public/Granted literature
- US2222997A Control means for airplanes Public/Granted day:1940-11-26
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