Invention Grant
- Patent Title: α4α7 peptide monomer and dimer antagonists
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Application No.: US16781516Application Date: 2020-02-04
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Publication No.: US11111272B2Publication Date: 2021-09-07
- Inventor: Ashok Bhandari , Dinesh V. Patel , Genet Zemede , Larry C. Mattheakis , David Liu
- Applicant: Protagonist Therapeutics, Inc.
- Applicant Address: US CA Newark
- Assignee: Protagonist Therapeutics, Inc.
- Current Assignee: Protagonist Therapeutics, Inc.
- Current Assignee Address: US CA Newark
- Agency: Cooley LLP
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/725 ; C07K7/06 ; A61K38/00
Abstract:
The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against α4β1 binding, and have high stability under gastrointestinal conditions.
Public/Granted literature
- US20200308229A1 NOVEL a4B7 PEPTIDE MONOMER AND DIMER ANTAGONISTS Public/Granted day:2020-10-01
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