Invention Grant
- Patent Title: T cell-antigen coupler with various construct optimizations
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Application No.: US16904451Application Date: 2020-06-17
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Publication No.: US11111298B2Publication Date: 2021-09-07
- Inventor: Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
- Applicant: McMaster University
- Applicant Address: CA Hamilton
- Assignee: McMaster University
- Current Assignee: McMaster University
- Current Assignee Address: CA Hamilton
- Agency: Goodwin Procter LLP
- Main IPC: C07K14/73
- IPC: C07K14/73 ; C07K16/28 ; A61K35/17 ; C07K16/32

Abstract:
A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
Public/Granted literature
- US20200308278A1 T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS Public/Granted day:2020-10-01
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