Invention Grant
- Patent Title: Chimeric polypeptides and methods of altering the membrane localization of the same
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Application No.: US15938600Application Date: 2018-03-28
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Publication No.: US11111310B2Publication Date: 2021-09-07
- Inventor: Stephen Santoro , Scott Coyle , Levi Rupp , Peter Emtage
- Applicant: Cell Design Labs, Inc.
- Applicant Address: US CA Emeryville
- Assignee: Cell Design Labs, Inc.
- Current Assignee: Cell Design Labs, Inc.
- Current Assignee Address: US CA Emeryville
- Agency: Barnes & Thornburg LLP
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C07K14/72 ; A61K38/17 ; A61P35/00 ; A61K39/00 ; A61K39/395 ; C07K14/705 ; C07K14/715 ; C07K16/28 ; C07K19/00 ; C12N15/62 ; C12N15/63 ; A61K48/00 ; C07K14/725 ; C12N5/0783
Abstract:
Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand binding domain (LBD) of a nuclear hormone receptor. Medical applications are provided, including controlling the toxicity of CAR T cells.
Public/Granted literature
- US20180319890A1 CHIMERIC POLYPEPTIDES AND METHODS OF ALTERING THE MEMBRANE LOCALIZATION OF THE SAME Public/Granted day:2018-11-08
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