Invention Grant
- Patent Title: Method for expressing protein gene in response to expression of miRNA
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Application No.: US16313322Application Date: 2017-06-27
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Publication No.: US11111503B2Publication Date: 2021-09-07
- Inventor: Hirohide Saito , Yoshihiko Fujita
- Applicant: KYOTO UNIVERSITY
- Applicant Address: JP Kyoto
- Assignee: KYOTO UNIVERSITY
- Current Assignee: KYOTO UNIVERSITY
- Current Assignee Address: JP Kyoto
- Agency: Myers Bigel, P.A.
- Priority: JPJP2016-126982 20160627
- International Application: PCT/JP2017/023513 WO 20170627
- International Announcement: WO2018/003779 WO 20180104
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N15/09 ; C12Q1/68 ; C12N5/10

Abstract:
An mRNA forcibly expresses a protein gene in response to a miRNA, and a method for forcibly expressing the same, are provided. An artificial mRNA comprising a sequence encoding a protein gene, a miRNA target sequence linked to the 3′-terminal side of a Poly A sequence, and a translational repression sequence linked to the 3′-terminal side of the miRNA target sequence; and a method for expressing a protein gene in response to the expression of a miRNA, comprising a step of introducing the artificial mRNA into a cell.
Public/Granted literature
- US20190256866A1 METHOD FOR EXPRESSING PROTEIN GENE IN RESPONSE TO EXPRESSION OF miRNA Public/Granted day:2019-08-22
Information query
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