A mode switching system including a first electronic device and the second electronic device is provided. The first electronic device includes a main control unit, a USB Type-C interface controller and a USB hub. The interface controller is coupled to the main control unit. The USB hub is coupled to the interface controller. The second electronic device is coupled to the interface controller of the first electronic device. The main control unit is configured to: (1) disable the USB hub in response to a mode switching instruction; (2) switch the mode of the interface controller from a first mode to a second mode; (3) command the interface controller to re-communicate with the second electronic device.