Computer implemented knowledge-based decision support system and method is provided. The method includes registering one or more software applications and data sources; defining processes to be implemented by executing the registered one or more software applications; orchestrating execution of the registered one or more software applications for implementing the processes; monitoring system performance based on the execution of the registered one or more software applications; generating analytics data related to the monitored system performance; updating a database with historical data using the generated analytics data; generating an analytical report by analyzing, using a machine learning technique, the historical data stored in the database as well as the generated analytics data; generating automatically user interface based on at least one of a layout and a specification provided by a user; modifying execution of the registered one or more software applications based on the generated analytical report; and displaying data from the generated analytical report using the user interface.