A method and device for generating a three dimensional (3D) bounding box of a region of interest (ROI) of a patient include receiving a two dimensional (2D) maximum intensity projection (MIP) image that is an axial view of the patient and a 2D MIP image that is a sagittal view of the patient. A first 2D bounding box of the ROI of the patient and a second 2D bounding box of the ROI of the patient are detected using the 2D MIP images. A 3D MIP image of the patient is received, and the 3D bounding box of the ROI of the patient is generated using the 3D MIP image, the first 2D bounding box, and the second 2D bounding box. The 3D MIP image including the 3D bounding box is provided.