A display device, a drive method therefor, and a drive system therefor are provided by embodiments of the present application. The drive method includes: detecting whether a spectrum of a drive signal is spread when the drive signal is received, and the drive signal is configured to drive the display panel; outputting a clock signal output from the control module to the source drive module if the spectrum of the drive signal is spread; performing spectrum spread on the clock signal according to a preset spread spectrum ratio if the spectrum of the drive signal is not spread; and outputting the clock signal with the spread spectrum to the source drive module.