Embodiments discussed herein facilitate classification of vascular plaque. One example embodiment can: access vascular imaging data comprising one or more slices, wherein each slice comprises a plurality of A-lines of that slice; for each A-line of the plurality of A-lines of each slice of the one or more slices: extract one or more features for that A-line, wherein the one or more features for that A-line comprise at least one of: one or more features extracted from that A-line, one or more features extracted from the slice comprising that A-line, or one or more features extracted from the vascular imaging data; provide the one or more features for that A-line to at least one classifier; and generate a classification of that A-line via the at least one classifier, wherein the classification of that A-line is one of fibrocalcific, fibrolipidic, or other.