A brightness compensation method and related product are disclosed. The method includes steps of receiving at least one compensation table sent from a mobile terminal by a driving device, and obtaining a target grayscale value of a target pixel point in a first display picture of the display device, determining a fixing value corresponding to the target pixel point according to the at least one compensation table, performing a brightness compensation to the target pixel point according to the fixing value, and driving the display device to display the first display picture after performing the brightness compensation. The embodiment of the present application can eliminate a brightness uneven phenomenon in the first display picture caused by attenuation of the luminous efficiency of the OLED device.