Methods of patterning openings for conductive contacts in a target layer of a semiconductor device and methods of forming conductive contacts. The method of patterning openings may be used to form contact openings in an inter-layer dielectric (ILD) layer of a semiconductor substrate for contacts to source/drain regions of FinFET devices. A hard mask layer may be patterned to form a cut mask by transferring slotted openings of a first middle layer of a tetra-layer photoresist and a cut MD pattern of a photoresist layer formed over the first middle layer of the tetra-layered photoresist using photolithography techniques. Once the cut mask is formed, contact openings are formed within the ILD layer down to the source/drain regions of the FinFET devices of the semiconductor substrate. The contact openings may be filled with conductive material(s) to define conductive contacts (e.g., conductive plugs).