Processing within a non-uniform memory access (NUMA) computing environment is facilitated by obtaining memory for a memory heap for an application of a virtualized environment of the NUMA computing environment, and assigning portions of memory of the obtained memory to locality domain-based freelists. The assigning including obtaining, for a selected portion of memory of the portions of memory, a locality domain within the NUMA computing environment with which the portion of memory is associated, and adding the selected portion of memory to a corresponding locality domain-based freelist of the locality domain-based freelists based on the associated locality domain of the portion of memory. Domain locality is then used in allocating the memory from the locality domain-based freelists to processors of the NUMA computing environment performing processing of the application.