A bioinformatics system for autonomous hypothesis generation for relatedness of seemingly independent concepts having tenuous or no prior known relationship in a knowledgebase. Independent concept pairs are identified in a question, and they are evaluated in light of lists of their similar concepts, and in light input documents, word embeddings, and co-occurrence matrices that are organized as a time series. Relationships between the independent concepts are hypothesized based on temporal analysis of relatedness measures of their similar concepts, measured via candidate connecting concepts.