A memory device applies different refresh rates to target data (or objective data) according to data characteristics (i.e., required reliability levels). The memory device includes a memory cell array provided with a plurality of memory cells, a row decoder configured to selectively activate word lines of the memory cell array in response to a row address signal, and a refresh controller configured to output the row address signal in response to the row address signal. The refresh controller controls a refresh ratio of a first storage region and a second storage region contained in the memory cell array in response to a changeable refresh control value.