An apparatus for measurement of an electrocardiogram signal using wireless communications includes a submodule measuring a first signal by a heartbeat signal provided via a first electrode when a flag signal is wirelessly received, and a main module wirelessly transmitting the flag signal according to a predetermined sampling period, and measuring a second signal by a heartbeat signal provided through a second electrode. The main module is configured to synchronize a measurement time of the second signal with a measurement time of the first signal by measuring the second signal in consideration of a wireless transmission time of the flag signal.