Invention Grant
- Patent Title: Use of chlorogenic acid in preparing pharmaceuticals for treatment of LAG-3-mediated disease
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Application No.: US16085392Application Date: 2017-02-20
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Publication No.: US11135160B2Publication Date: 2021-10-05
- Inventor: Jie Zhang , Xiaoguang Chen , Nina Xue , Mengtian Zhang
- Applicant: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO. LTD
- Applicant Address: CN Sichuan
- Assignee: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO. LTD
- Current Assignee: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO. LTD
- Current Assignee Address: CN Sichuan
- Agency: Novick, Kim & Lee, PLLC
- Agent Allen Xue
- Priority: CN201610149050.5 20160315
- International Application: PCT/CN2017/074065 WO 20170220
- International Announcement: WO2017/157131 WO 20170921
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/216 ; A61K9/20 ; A61P31/20 ; A61P35/02 ; A61P31/04 ; A61P35/00 ; A61K9/16 ; C07C69/732
Abstract:
Provided are a use of chlorogenic acid in preparing pharmaceuticals for the inhibition of LAG-3 and a use of chlorogenic acid in preparing pharmaceuticals for the treatment of LAG-3-mediated diseases. The inhibition of LAG-3 by chlorogenic acid is useful in cancer therapy, anti-viral therapy, and sepsis treatment. The oral bioavailability of chlorogenic acid is enhanced by preparing chlorogenic acid as a gastric floating tablet.
Public/Granted literature
- US20190175499A1 USE OF CHLOROGENIC ACID IN PREPARING PHARMACEUTICALS FOR TREATMENT OF LAG-3-MEDIATED DISEASE Public/Granted day:2019-06-13
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