Invention Grant
- Patent Title: Modified ebolavirus glycoproteins comprising mutations in the head and base domains that increase antibody cross-reactivity
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Application No.: US16084151Application Date: 2017-03-27
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Publication No.: US11135280B2Publication Date: 2021-10-05
- Inventor: Mohammad Javad Aman , Katie A. Howell , Edgar Davidson , Benjamin J. Doranz
- Applicant: INTEGRATED BIOTHERAPEUTICS, INC. , INTEGRAL MOLECULAR, INC.
- Applicant Address: US MD Rockville; US PA Philadelphia
- Assignee: INTEGRATED BIOTHERAPEUTICS, INC.,INTEGRAL MOLECULAR, INC.
- Current Assignee: INTEGRATED BIOTHERAPEUTICS, INC.,INTEGRAL MOLECULAR, INC.
- Current Assignee Address: US MD Rockville; US PA Philadelphia
- Agency: Thompson Coburn LLP
- Agent William A. Holtz
- International Application: PCT/US2017/024320 WO 20170327
- International Announcement: WO2017/172622 WO 20171005
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C07K14/005 ; C12N15/86
Abstract:
Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.
Public/Granted literature
- US20190381162A1 PAN FILOVIRUS VACCINE COMPOSITIONS AND METHODS OF MAKING Public/Granted day:2019-12-19
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