Invention Grant
- Patent Title: Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
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Application No.: US16490157Application Date: 2018-03-02
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Publication No.: US11136324B2Publication Date: 2021-10-05
- Inventor: Peng Gao , Guangjun Sun , Shaobao Wang , Fujun Zhang , Lei Liu , Rudi Bao
- Applicant: Jiangsu Hansoh Pharmaceutical Group Co., Ltd. , Shanghai Hansoh Biomedical Co., Ltd.
- Applicant Address: CN Jiangsu; CN Shanghai
- Assignee: Jiangsu Hansoh Pharmaceutical Group Co., Ltd.,Shanghai Hansoh Biomedical Co., Ltd.
- Current Assignee: Jiangsu Hansoh Pharmaceutical Group Co., Ltd.,Shanghai Hansoh Biomedical Co., Ltd.
- Current Assignee Address: CN Jiangsu; CN Shanghai
- Agency: Ice Miller LLP
- Priority: CN201710123799.7 20170303,CN201710713967.8 20170818,CN201810045023.2 20180117
- International Application: PCT/CN2018/077869 WO 20180302
- International Announcement: WO2018/157856 WO 20180907
- Main IPC: A61K31/4178
- IPC: A61K31/4178 ; C07D233/54 ; C07D487/04 ; C07D498/04
Abstract:
An amide derivative inhibitor and a preparation method and an application thereof. Specifically relating to the compound shown in general formula (I), a preparation method for same, a pharmaceutical composition comprising said compound, and an application of same as an ASK inhibitor for the treatment of neurodegenerative disease, cardiovascular disease, inflammation, autoimmune and metabolic disease, each of the substituents in the general formula (I) being as defined in the description.
Public/Granted literature
- US20210032249A1 AMIDE DERIVATIVE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF Public/Granted day:2021-02-04
Information query
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