Invention Grant
- Patent Title: Recombinant HIV-1 envelope proteins and their use
-
Application No.: US16756777Application Date: 2018-10-16
-
Publication No.: US11136356B2Publication Date: 2021-10-05
- Inventor: Peter Kwong , John Mascola , Gwo-Yu Chuang , Hui Geng , Yongping Yang , Cheng Cheng , Jeffrey Boyington , Yen-Ting Lai
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2018/056135 WO 20181016
- International Announcement: WO2019/079337 WO 20190425
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/00 ; A61K39/12 ; A61K39/21 ; C12N7/00 ; C07K14/16 ; A61K39/39
Abstract:
Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject.
Public/Granted literature
- US20210188921A1 RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE Public/Granted day:2021-06-24
Information query
