Invention Grant
- Patent Title: Dual function proteins comprising FGF21 mutant protein and pharmaceutical composition comprising same
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Application No.: US15768865Application Date: 2016-10-28
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Publication No.: US11136364B2Publication Date: 2021-10-05
- Inventor: Jun Hwan Kim , Seyoung Lim , Minji Seo , Hyun Ho Choi , Dohoon Kim , Mi Kyeong Ju , Ju-Young Park , Seul Gi Kim , Sangmyoun Lim , Jong Gyun Kim , Su Youn Nam
- Applicant: YUHAN CORPORATION
- Applicant Address: KR Seoul
- Assignee: YUHAN CORPORATION
- Current Assignee: YUHAN CORPORATION
- Current Assignee Address: KR Seoul
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2015-0150576 20151028
- International Application: PCT/KR2016/012300 WO 20161028
- International Announcement: WO2017/074123 WO 20170504
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; C07K14/575 ; C07K14/605

Abstract:
The present invention provides a dual function protein prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin, which has improved pharmacological efficacy, in vivo duration and protein stability. A dual function protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.
Public/Granted literature
- US20200024318A1 DUAL FUNCTION PROTEINS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Public/Granted day:2020-01-23
Information query
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