Invention Grant
- Patent Title: Antibodies and antibody fragments for binding to NAV1.9 polypeptides and methods for using same to treat pain-related disease
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Application No.: US16657515Application Date: 2019-10-18
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Publication No.: US11136382B2Publication Date: 2021-10-05
- Inventor: Daichang Yang
- Applicant: POPULAS BIOPHARMACEUTICAL (WUHAN) LIMITED
- Applicant Address: CN Wuhan
- Assignee: POPULAS BIOPHARMACEUTICAL (WUHAN) LIMITED
- Current Assignee: POPULAS BIOPHARMACEUTICAL (WUHAN) LIMITED
- Current Assignee Address: CN Wuhan
- Agency: Greer, Burns & Crain, Ltd.
- Agent Gregory P. Einhorn
- Priority: CN201710093290.2 20170221
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; C07K16/28 ; A61K39/00
Abstract:
The present invention provides an antibody or antibody fragment thereof for a targeted cytomembrane voltage-gated sodium channel α subunit Nav1.9. The specific binding target is a S3-4 ring of a voltage sensor paddle of a domain II of the voltage-gated sodium channel α subunit. The antibody or antibody fragment thereof is able to inactivate a voltage sensor valve, to make sodium ions unable to enter nerve cells normally, thereby achieving the effect of treating and relieving pains.
Public/Granted literature
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