Invention Grant
- Patent Title: TCR libraries
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Application No.: US15759772Application Date: 2016-09-15
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Publication No.: US11136575B2Publication Date: 2021-10-05
- Inventor: Peter Eamon Molloy , Arsen Valeryevich Volkov , Dhaval Jaykant Sangani , Graham Anthony Hood , Chandramouli Reddy Chillakuri
- Applicant: IMMUNOCORE LIMITED
- Applicant Address: GB Abingdon
- Assignee: IMMUNOCORE LIMITED
- Current Assignee: IMMUNOCORE LIMITED
- Current Assignee Address: GB Abingdon
- Agency: Fenwick & West LLP
- Priority: GB1516277 20150915
- International Application: PCT/EP2016/071761 WO 20160915
- International Announcement: WO2017/046201 WO 20170323
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C12N15/10 ; C07K14/725 ; C07K14/74 ; C12N15/66 ; C12N15/85 ; C40B40/02

Abstract:
The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain comprising an alpha chain variable domain and a beta chain comprising a beta chain variable domain and the library comprises more than one TRAV gene product and/or more than one TRBV gene product, wherein the beta chain variable domain does not comprise one or more of a TRBV5-1, 5-3, 5-4, 5-5, 5-6, 5-7 or 5-8 gene product and wherein the plurality of TCRs do not consist essentially of TCRs comprising a TRAV12-2 gene product from a natural repertoire and a TRBV6 gene product from a natural repertoire and TCRs comprising a TRAV21 gene product from a natural repertoire and a TRBV6 gene product from a natural repertoire.
Public/Granted literature
- US20190048333A1 TCR LIBRARIES Public/Granted day:2019-02-14
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