An in-vehicle noise-cancellation system may optimize far-end user experience. The noise-cancellation system may incorporate real-time acoustic input from the vehicle, as well microphones from a telecommunications device. Audio signals from small, embedded microphones mounted in the vehicle can be processed and mixed into an outgoing telecom signal to effectively cancel acoustic energy from one or more unwanted sources in the vehicle. Multiple microphones may be mounted to headrests and spaced apart in one or more directions to give an indication of the direction of incoming sound from one or more listening zones so that sounds from certain zones may be suppressed. Unwanted noise captured by the embedded microphones may be used as direct inputs to the noise-cancellation system. As direct inputs, these streams can, therefore, be cancelled from the outgoing telecom signal, thus providing the user's far-end correspondent with much higher signal-to-noise ratio, call quality, and speech intelligibility.