This application relates to a drive method of a display panel. The method includes dividing sub pixels of the same color on the display panel into a plurality of sub pixel groups, acquiring a difference curve that is of each color sub pixel and that is between a curve of brightness changing with a drive voltage at a front view angle and a curve of brightness changing with the drive voltage at a side view angle, and for each color sub pixel, respectively regulating gamma values of various sub pixel groups based on the difference curve.