Disclosed are a driving method for a display panel, and a display device based on a viewing distance. The display panel includes a plurality of pixels arranged in an array, and each pixel includes sub-pixels of at least three colors. A viewing distance is acquired between a user and the display panel; the number of pixels to be lightened in the display panel is determined based on the viewing distance; the larger the viewing distance is, the smaller the number of pixels to be lightened in the display panel is; and displaying is performed based on the determined number of pixels to be lightened.