Audio processing systems and methods include an audio sensor array configured to receive a multichannel audio input and generate a corresponding multichannel audio signal and target-speech detection logic and an automatic speech recognition engine or VoIP application. An audio processing device includes a target speech enhancement engine configured to analyze a multichannel audio input signal and generate a plurality of enhanced target streams, a multi-stream target-speech detection generator comprising a plurality of target-speech detector engines each configured to determine a probability of detecting a specific target-speech of interest in the stream, wherein the multi-stream target-speech detection generator is configured to determine a plurality of weights associated with the enhanced target streams, and a fusion subsystem configured to apply the plurality of weights to the enhanced target streams to generate an enhancement output signal.