Techniques are described using Position Dependent Intra Prediction Combination (PDPC) and multiple reference lines. For example, a video coder (e.g., an encoder and/or decoder) can predict an initial prediction sample value for a sample of a current block using an intra-prediction mode. The initial prediction sample value can be predicted from a first neighboring block and/or a second neighboring block of the current block. One or more reference sample values can be determined from at least one line of multiple lines of reference samples from the first neighboring block and/or the second neighboring block. At least one of the lines from the multiple lines used for determining the reference sample value(s) is not adjacent to the current block. A final prediction sample value can be determined for the sample of the current block, such as by modifying the initial prediction sample value using the one or more reference sample values.