A pop-up blocker application detects and remediates malicious pop-up loops. The pop-up blocker application intercepts a call from a web page for initiating a pop-up browser window in a web browser. The pop-up blocker application updates a count of pop-up initiating calls associated with the web page occurring within a pre-defined time window. The updated count is compared to a threshold to determine whether the count meets a threshold indicative of a malicious pop-up loop. Responsive to the count meeting the threshold, the pop-up blocker applications takes a remedial action, such as navigating away from the web page.