A display panel and chip-on-film (COF) package bonding structure is provided and includes a display panel including a panel substrate and a plurality of panel bonding pins. The panel bonding pins are disposed on the panel substrate and are arranged along a lateral direction. Each of the panel bonding pins is trapezoidal and is directed along a longitudinal direction. A COF package is bonded to the display panel and includes a package substrate and a plurality of package bonding pins. The package bonding pins are disposed on the package substrate, are arranged along the lateral direction, and are bonded to the panel bonding pins respectively. Each of the package bonding pins is trapezoidal and along the longitudinal direction. The trapezoidal panel bonding pins and package bonding pins can be aligned with and contacts each other.