The present disclosure provides methods and devices for determining liver segments in a medical image. The methods may be implemented on the devices. The method may include: obtaining a scan image; obtaining a segmentation protocol; obtaining segmentation information associated with the scan image; determining one or more marked points based on the segmentation information and the segmentation protocol; determining one or more segmentation surfaces based on the one or more marked points; and determining a segmentation result of at least part of a liver in the scan image based on the one or more segmentation surfaces.