There is provided a method for generating instructions for adjusting a medical treatment of a patient, comprising: detecting an indication of a new symptom appearing in a patient being treated with medications for medical condition(s), computing a value indicative of risk of the new symptom being an adverse drug reaction (ADR) of one or a combination of the medications, detecting an indication of another new medication for treating the patient, computing likelihood of PC when the new medication is for treating the new symptom and the value is according to a requirement, generating a request for substitute medication(s) for the one or combination of medications when likelihood of PC is detected, and generating instructions for adjusting treatment of the patient by substituting the one or combination of medications with the substitute medication(s), and for terminating administration of the new medication or avoiding administration of the new medication.