Systems and methods are provided for encoding a multi-pixel caching scheme for lossless encoders. The systems and methods can include obtaining a sequence of pixels, determining repeating sub-sequences of the sequence of pixels consisting of a single repeated pixel and non-repeating sub-sequences of the sequence of pixels, responsive to the determination, encoding the repeating sub-sequences using a run-length of the repeated pixel and encoding the non-repeating sub-sequences using a multi-pixel cache, wherein the encoding using a multi-pixel cache comprises, encoding non-repeating sub-sequences stored in the multi-pixel cache as the location of the non-repeating sub-sequences in the multi-pixel cache, and encoding non-repeating sub-sequences not stored in the multi-pixel cache using the value of the pixels in the non-repeating sub-sequences.