A sterile enclosure to bring a non-sterile hand-held electronic device such as a smartphone or a tablet into a sterile field comprises a rigid frame, a rigid base and a device holder configured to accept the hand-held device thereon. The use of the device holder to contain the hand-held device prior to engaging with the base and positioning the device therein, allows avoiding contamination of sterile components during use. A sterility indicator is also provided to continuously monitor the sterile enclosure for a possible breach in sterility while inside the sterile field.