Invention Grant
- Patent Title: Index for quanitification of bowman's layer roughness for diagnosis of disease and prognosis of treatments in human cornea
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Application No.: US16060807Application Date: 2016-12-08
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Publication No.: US11191430B2Publication Date: 2021-12-07
- Inventor: Abhijit Sinha Roy , Rohit Shetty , Bhujang Shetty
- Applicant: Narayana Nethralaya Foundation
- Applicant Address: IN Bangalore
- Assignee: Narayana Nethralaya Foundation
- Current Assignee: Narayana Nethralaya Foundation
- Current Assignee Address: IN Bangalore
- Agency: Westman Champlin & Koehler, P.A.
- Agent Steven M. Koehlet
- Priority: IN6539/CHE/2015 20151208
- International Application: PCT/IB2016/057422 WO 20161208
- International Announcement: WO2017/098424 WO 20170615
- Main IPC: A61B3/107
- IPC: A61B3/107 ; A61B3/10 ; A61F9/008 ; A61B3/00 ; G16H30/20 ; G16H70/60

Abstract:
A Bowman's Refractive Index (BRI) for quantification of microdistortions in Bowman's Layer (BL) after Small Incision Lenticule Extraction (SMILE) is defined for a patient. BRI is summation of one or more areas of the OCT image of anterior edge of Bowman's layer, quantifies the smoothness of the Bowman's layer. The anterior edge of Bowman's layer is segmented into pixels. After segmentation, a 3rd order polynomial is curve fit to the segmented pixels of the edge of Bowman's layer. BRI is calculated by segmentation of the 3-Dimensional (3-D) OCT image. BRI acts as a marker for mechanical stability and is useful for diagnosis of disease and prognosis of treatments in human.
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