The present invention relates to an oil-in-water emulsion comprising a glycopyrronium salt and an emulsifier system comprising at least one macrogol glycerol fatty acid ester, at least one glycerol fatty acid ester and at least one fatty alcohol. Moreover, the present invention relates to such an emulsion for use as a medicament, in particular for treating and preventing diseases in conjunction with excessive sweating. In addition the present invention relates to the non-therapeutic use of such an oil-in-water emulsion for topical application on the skin of a mammal in order to reduce sweating.